L-Dopa and Brain Serotonin System Dysfunction
نویسندگان
چکیده
منابع مشابه
l-Dopa and Brain Serotonin System Dysfunction
L-dopa is used to treat the motor symptoms associated with Parkinson's disease, a neurodegenerative movement disorder characterized by a loss of dopamine neurons. L-dopa is the precursor to dopamine and crosses the blood-brain barrier to increase dopamine neurotransmission. This review will focus on the findings that dopamine produced from L-dopa is mediated in part by serotonin neurons. Direct...
متن کاملInvolvement of the serotonin system in L-dopa-induced dyskinesias.
The ability of L-dopa to relieve the motor impairments in Parkinson's disease patients declines over time, and side-effects, such as dyskinesias, appear--limiting the use of the drug in the advanced stage of the disease. Serotonergic neurons are able to convert L-dopa to dopamine and to store this neurotransmitter in synaptic vesicles. This peculiarity might be very important in the advanced di...
متن کاملChronic oral l-DOPA increases dopamine and decreases serotonin excretions.
Given the common pathways for uptake and synthesis for dopamine and serotonin, enhanced renal dopamine synthesis in response to increased substrate 3,4-dihydroxyphenylalanine (l-DOPA) is postulated to decrease renal serotonin synthesis. The present study compared the effects of chronic oral administration ofl-DOPA on dopamine and serotonin excretion in vivo, with the effects of enhanced dopamin...
متن کاملSerotonin System Implication in l-DOPA-Induced Dyskinesia: From Animal Models to Clinical Investigations
In the recent years, the serotonin system has emerged as a key player in the induction of l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease. In fact, serotonin neurons possess the enzymatic machinery able to convert exogenous l-DOPA to dopamine (DA), and mediate its vesicular storage and release. However, serotonin neurons lack a feedback control mechanism able to regulate...
متن کاملL-Dopa and Behavior
to include the "why" of procedures, but rather presents step-by-step instructions and recipes for the bench technologist. The first of the three sections deals with biochemical identification tests, from acetate utilization to Voges-Proskauer. Each includes descriptions of purpose, principle, mechanisms, equipment and reagents, method, and interpretation. The format is short, lucid, and informa...
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ژورنال
عنوان ژورنال: Toxics
سال: 2015
ISSN: 2305-6304
DOI: 10.3390/toxics3010075